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Resident Research »  Leadership »  Research Committee Members »  Tippi MacKenzie, M.D.

Tippi MacKenzie, M.D.

  • Professor of Surgery
  • Division of Pediatric Surgery
  • Benioff UCSF Professor in Children’s Health
  • Director, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF
  • Co-Director, Center for Maternal-Fetal Precision Medicine
  • John G. Bowes Distinguished Professor in Stem Cell and Tissue Biology

Contact Information

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  • 1987-91, Harvard University, B.A., Biochemistry
  • 1992-97, Stanford University School of Medicine, M.D., Medicine
  • 1998-99, Brigham and Women's Hospital, Resident, Surgery
  • 2002-04, Brigham and Women's Hospital, Resident, Surgery
  • 2004-05, Brigham and Women's Hospital, Chief Resident, Surgery
  • 1999-02, Children's Hospital of Philadelphia, Fellow, Fetal Therapy
  • 2005-07, Children's Hospital of Philadelphia, Fellow, Pediatric Surgery
  • American Board of Surgery, 2006
  • Fetal Treatment Center
  • Biomedical Sciences Program
  • Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
  • Center for Maternal-Fetal Precision Medicine
  • Advanced Laparoscopy
  • Birth Defects
  • Endocrine and Biliary Surgery
  • Fetal Surgery
  • Pediatric Surgery
  • In-Utero Stem Cell Transplantation

Dr. Tippi MacKenzie is Professor of Surgery at the UCSF Division of Pediatric Surgery and the Fetal Treatment Center. Dr. MacKenzie obtained her undergraduate degree in Biochemistry at Harvard, then came to the Bay Area for medical school at Stanford. She did her surgical residency at Brigham and Women's Hospital in Boston. During this time, she took three years to do research on fetal surgery and in utero stem cell transplantation at the Children's Hospital of Philadelphia. Following residency, she returned to CHOP for her clinical pediatric surgery fellowship.

Dr. MacKenzie's clinical interests include fetal surgery, advanced laparoscopy, and endocrine and biliary surgery.

Dr. MacKenzie has an active laboratory and is a member of the Biomedical Sciences Program and the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research. Her research focus is on mechanisms of tolerance induction following in utero stem cell transplantation  and the pathophysiology of prenatally diagnosed diseases, such as congenital diaphragmatic hernia and gastroschisis, to identify biomarkers that predict prognosis and molecular pathways that may be targets for prenatal intervention.

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  • Phase 1 Study of In Utero Enzyme Replacement Therapy for the Treatment of Lysosomal Storage Diseases
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    Sep 2022
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    Apr 2027
    Principal Investigator
  • Developing gene therapy strategies to treat alpha thalassemia
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    Jan 2022
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    Dec 2025
    Principal Investigator
  • Autoimmune Regulator gene (Aire)-mediated tolerance to pregnancy-associated self-antigens
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    Aug 2019
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    Jul 2024
    Principal Investigator
  • In utero hematopoietic stem cell transplantation for the treatment of fetuses with alpha thalassemia major (phase I clinical trial)
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    Aug 2017
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    Jul 2022
    Principal Investigator
  • A precision medicine approach to detect dysbiosis and immune activation in preterm labor
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    Jul 2017
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    Jun 2021
    Principal Investigator
  • T cell activation and the breakdown of maternal-fetal tolerance in preterm labor
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    Jun 2015
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    May 2020
    Principal Investigator
  • Maternal and fetal immune responses to in utero HSC transplantation
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    Jul 2010
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    May 2015
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  • IN UTERO MESENCHYMAL STEM CELL TRANSPLANTATION
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    Jan 2000
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    Jan 0001
    Principal Investigator
Data provided by UCSF Profiles, powered by CTSI
MOST RECENT PUBLICATIONS FROM A TOTAL OF 101
Data provided by UCSF Profiles, powered by CTSI
  1. Clarke MT, Remesal L, Lentz L, Tan DJ, Young D, Thapa S, Namuduri SR, Borges B, Kirn G, Valencia J, Lopez ME, Lui JH, Shiow LR, Dindot S, Villeda S, Sanders SJ, MacKenzie TC. Prenatal delivery of a therapeutic antisense oligonucleotide achieves broad biodistribution in the brain and ameliorates Angelman syndrome phenotype in mice. Mol Ther. 2024 Apr 03; 32(4):935-951. View in PubMed
  2. Herzeg A, Borges B, Lianoglou BR, Gonzalez-Velez J, Canepa E, Munar D, Young SP, Bali D, Gelb MH, Chakraborty P, Kishnani PS, Harmatz P, Cohen JL, MacKenzie TC. Intrauterine enzyme replacement therapies for lysosomal storage disorders: Current developments and promising future prospects. Prenat Diagn. 2023 12; 43(13):1638-1649. View in PubMed
  3. Lowther C, Valkanas E, Giordano JL, Wang HZ, Currall BB, O'Keefe K, Pierce-Hoffman E, Kurtas NE, Whelan CW, Hao SP, Weisburd B, Jalili V, Fu J, Wong I, Collins RL, Zhao X, Austin-Tse CA, Evangelista E, Lemire G, Aggarwal VS, Lucente D, Gauthier LD, Tolonen C, Sahakian N, Stevens C, An JY, Dong S, Norton ME, MacKenzie TC, Devlin B, Gilmore K, Powell BC, Brandt A, Vetrini F, DiVito M, Sanders SJ, MacArthur DG, Hodge JC, O'Donnell-Luria A, Rehm HL, Vora NL, Levy B, Brand H, Wapner RJ, Talkowski ME. Systematic evaluation of genome sequencing for the diagnostic assessment of autism spectrum disorder and fetal structural anomalies. Am J Hum Genet. 2023 09 07; 110(9):1454-1469. View in PubMed
  4. Yu TW, Kingsmore SF, Green RC, MacKenzie T, Wasserstein M, Caggana M, Gold NB, Kennedy A, Kishnani PS, Might M, Brooks PJ, Morris JA, Parisi MA, Urv TK. Are we prepared to deliver gene-targeted therapies for rare diseases? Am J Med Genet C Semin Med Genet. 2023 03; 193(1):7-12. View in PubMed
  5. Cohen JL, Chakraborty P, Fung-Kee-Fung K, Schwab ME, Bali D, Young SP, Gelb MH, Khaledi H, DiBattista A, Smallshaw S, Moretti F, Wong D, Lacroix C, El Demellawy D, Strickland KC, Lougheed J, Moon-Grady A, Lianoglou BR, Harmatz P, Kishnani PS, MacKenzie TC. In Utero Enzyme-Replacement Therapy for Infantile-Onset Pompe's Disease. N Engl J Med. 2022 12 08; 387(23):2150-2158. View in PubMed
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