University of California San Francisco

Sophia Hernandez, MD, MAS

Sophia Hernandez
Sophia Hernandez, MD, MAS

Senior Resident (PGY-4)
General Surgery

[email protected]

Biography

Sophia Hernandez, M.D. is a general surgery resident with the UCSF Department of Surgery. She
is completing her dedicated research years as a T32 Surgical Oncology Research Fellow in the
Maker lab where she is developing novel immunotherapies and delivery systems for the
treatment of colorectal liver metastasis. She completed her undergraduate studies at California
State University, Fullerton where she earned a degree in Biological Science. She continued her
education at UCSF, where she obtained her medical degree and a Master of Advanced Studies
(MAS) in Clinical Research with a focus on Data Science.

Dr. Hernandez has a strong foundation in translational research, data science, and clinical
research. As an undergraduate, she was awarded the California Institute for Regenerative
Medicine (CIRM) Bridges to Stem Cell Research Award where she utilized CRISPR/Cas9
technology to differentiate human embryonic stem cells. During her medical training, she was
awarded the UCSF Summer Explore Scholar Grant to study fetal immune cell activation in
preterm labor under the mentorship of Dr. Tippi Mackenzie. Additionally, as a medical student
she obtained NIH funding as a TL-1 Medical Student Research Fellow to develop a predictive
model to evaluate the malignant potential of pancreatic cystic neoplasms using radiomic
features and cyst fluid analytes under the mentorship of Dr. Kimberly Kirkwood.

Dr. Hernandez aims to integrate her surgical training with her passion for translational research
and clinical trials as an academic surgical oncologist.

Education

Institution Degree Dept or School End Date
University of California, San Francisco MD 06/2021
California State University, Fullerton BS Cell and Developmental Biology 06/2015
University of California, San Francisco MAS Data Science 06/2015

Awards & Honors

Award Conferred By Date
T32 Surgical Oncology Research Fellowship UCSF 2024/2026
TL1 Medical Student Research Fellowship UCSF 2019/2020
California Institute of Regenerative Medicine (CIRM) Bridges to Stem Cell Research Scholar 2013/2014
CSU Program for Education and Research in Biotechnology Presidents' Commission Scholar CSUF 2012

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 10
  1. Survival after resection of pancreatic cancer is similar with neoadjuvant gemcitabine-nab-paclitaxel or mFOLFIRINOX but one size will not fit all in the future.
    Hernandez S, Maker AV| | PubMed
  2. Re-evaluating the Role of Neoadjuvant Chemotherapy in Early-Stage Pancreatic Ductal Adenocarcinoma: Unveiling the Impact of Immortal Time Bias on Survival.
    Ashraf Ganjouei A, Wang J, Hernandez S, Foroutani L, Hernandez FR, Hirose K, Nakakura E, Corvera C, Alseidi A, Adam MA| | PubMed
  3. Prevalence and Size-Based Risk Categorization of Pancreatic Cysts Among Asymptomatic Individuals With Screening MRI.
    Wong P, Pollini T, Hernandez S, Zampese M, Todeschini L, Aguilar LL, Basar SA, Hashemi S, Maker AV| | PubMed
  4. The science of tumor-infiltrating lymphocytes (TIL): perspectives from the SITC Surgery Committee.
    Coukos G, Donia M, Gastman BR, Goff SL, Gros A, Harari A, Hernandez S, Ito F, Maker AV, Mullinax JE, Murthy P, Pai SI, Prabhakaran S, Restifo NP, Silver NL, Marincola Smith P, Turcotte S, Wagner PL, Yang JC, Lotze MT| | PubMed
  5. Combination LIGHT overexpression and checkpoint blockade disrupts the tumor immune environment impacting colorectal liver metastases.
    Keenan BP, Qiao G, Kunda N, Kone L, Guldberg SM, Todeschini L, Kumar P, Pollini T, Hernandez S, Qin J, Fong L, Spitzer MH, Prabhakar BS, Maker AV| | PubMed
  6. Minimally Invasive Versus Open Resection for Solid Pseudopapillary Tumors of the Pancreas: A Propensity Score-Matched Analysis.
    Wong P, Todeschini L, Pollini T, Hernandez S, Zampese M, Aguilar LL, Peng JS, Thornblade LW, Adam MA, Alseidi A, Corvera CU, Hirose K, Kirkwood KS, Nakakura EK, Maker AV| | PubMed
  7. Novel Computational Analysis Identifies Cytotoxic Lymphocyte-to-Monocyte Balance in Tumors as a Predictor of Recurrence-Free Survival in Colorectal Carcinoma.
    Fernandez M, Todeschini L, Keenan BP, Rosenberg D, Hernandez S, Zampese M, Qiao G, Pollini T, Maker AV| | PubMed
  8. ASO Author Reflections: Precision Immunoprofiling of the Tumor Microenvironment Predicts Recurrence in Advanced Colorectal Cancer.
    Todeschini L, Hernandez S, Maker AV| | PubMed
  9. Impact of coronary artery stenting on perioperative mortality and complications in patients undergoing pancreaticoduodenectomy.
    Wong P, Tran TB, Pollini T, Hernandez S, Zampese M, Todeschini L, Aguilar LL, Maker VK, Maker AV| | PubMed
  10. Ongoing Failure to Deliver Guideline-Concordant Care for Patients with Pancreatic Cancer.
    Ejie J, Ashraf Ganjouei A, Hernandez S, Wang JJ, Romero-Hernandez F, Foroutani L, Hirose K, Nakakura E, Corvera CU, Alseidi A, Adam MA| | PubMed