University of California San Francisco

kyle-cromer-144x192
Kyle
Cromer
PhD

Assistant Professor of Surgery
Division of Pediatric Surgery

Address

35 Medical Center Way, #001
San Francisco, CA 94143
United States

Email: [email protected]

ORCID: 0000-0002-8198-5010

Awards & Honors

Award Conferred By Date
Catalyst Award UCSF Innovation Ventures 2024/2025
Mary Anne Koda-Kimble Award UCSF School of Pharmacy 2024/2025
Junior Faculty Scholar Award American Society of Hematology 2023/2024
New Frontier Research Award UCSF Program for Breakthrough Biomedical Research 2023/2024
Career Development Award American Society of Gene & Cell Therapy 2022/2022
Honorary Mention Prix Ars Electronica 2021/2021
Star Mentor Award Stanford Bio-X 2021/2021

Education

Institution Degree Dept or School End Date
Stanford University Instructor Pediatrics 05/2022
Stanford University Postdoc Pediatrics 06/2020
Harvard Medical School Postdoc Genetics 05/2016
Yale University PhD Genetics 05/2014

Grants and Funding

  • Enrichment of erythroid cells using truncated EPO receptor | American Society of Hematology | 2023-07-01 - 2026-06-28 | Role: Principal Investigator
  • Developing gene therapy strategies to correct a-thalassemia | NIH NHLBI | 2022-01-01 - 2025-12-31 | Role: Co-Investigator
  • Developing base editor-mediated correction strategies for a-thalassemia | UCSF | 2023-07-01 - 2025-06-28 | Role: Principal Investigator
  • Development of inducible signaling receptors to increase production of clinically relevant cell types | UCSF Program for Breakthrough Biomedical Research | 2023-06-01 - 2024-05-30 | Role: Principal Investigator
  • Developing a CRISPR/AAV-mediated genome editing strategy to correct a-thalassemia | American Society of Gene & Cell Therapy | 2022-01-01 - 2022-12-31 | Role: Principal Investigator

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 17
  1. Enhancement of erythropoietic output by Cas9-mediated insertion of a natural variant in haematopoietic stem and progenitor cells.
    Luna SE, Camarena J, Hampton JP, Majeti KR, Charlesworth CT, Soupene E, Selvaraj S, Jia K, Sheehan VA, Cromer MK, Porteus MH| | PubMed
  2. Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells.
    Fowler JL, Zheng SL, Nguyen A, Chen A, Xiong X, Chai T, Chen JY, Karigane D, Banuelos AM, Niizuma K, Kayamori K, Nishimura T, Cromer MK, Gonzalez-Perez D, Mason C, Liu DD, Yilmaz L, Miquerol L, Porteus MH, Luca VC, Majeti R, Nakauchi H, Red-Horse K, Weissman IL, Ang LT, Loh KM| | PubMed
  3. Transient inhibition of 53BP1 increases the frequency of targeted integration in human hematopoietic stem and progenitor cells.
    Baik R, Cromer MK, Glenn SE, Vakulskas CA, Chmielewski KO, Dudek AM, Feist WN, Klermund J, Shipp S, Cathomen T, Dever DP, Porteus MH| | PubMed
  4. High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition.
    Selvaraj S, Feist WN, Viel S, Vaidyanathan S, Dudek AM, Gastou M, Rockwood SJ, Ekman FK, Oseghale AR, Xu L, Pavel-Dinu M, Luna SE, Cromer MK, Sayana R, Gomez-Ospina N, Porteus MH| | PubMed
  5. Comparative analysis of CRISPR off-target discovery tools following ex vivo editing of CD34+ hematopoietic stem and progenitor cells.
    Cromer MK, Majeti KR, Rettig GR, Murugan K, Kurgan GL, Bode NM, Hampton JP, Vakulskas CA, Behlke MA, Porteus MH| | PubMed
  6. CRISPR nuclease off-target activity and mitigation strategies.
    Wienert B, Cromer MK| | PubMed
  7. Ultra-deep sequencing validates safety of CRISPR/Cas9 genome editing in human hematopoietic stem and progenitor cells.
    Cromer MK, Barsan VV, Jaeger E, Wang M, Hampton JP, Chen F, Kennedy D, Xiao J, Khrebtukova I, Granat A, Truong T, Porteus MH| | PubMed
  8. Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease.
    Lattanzi A, Camarena J, Lahiri P, Segal H, Srifa W, Vakulskas CA, Frock RL, Kenrick J, Lee C, Talbott N, Skowronski J, Cromer MK, Charlesworth CT, Bak RO, Mantri S, Bao G, DiGiusto D, Tisdale J, Wright JF, Bhatia N, Roncarolo MG, Dever DP, Porteus MH| | PubMed
  9. Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells.
    Cromer MK, Camarena J, Martin RM, Lesch BJ, Vakulskas CA, Bode NM, Kurgan G, Collingwood MA, Rettig GR, Behlke MA, Lemgart VT, Zhang Y, Goyal A, Zhao F, Ponce E, Srifa W, Bak RO, Uchida N, Majeti R, Sheehan VA, Tisdale JF, Dever DP, Porteus MH| | PubMed
  10. Improved Genome Editing through Inhibition of FANCM and Members of the BTR Dissolvase Complex.
    de Alencastro G, Puzzo F, Pavel-Dinu M, Zhang F, Pillay S, Majzoub K, Tiffany M, Jang H, Sheikali A, Cromer MK, Meetei R, Carette JE, Porteus MH, Pekrun K, Kay MA| | PubMed
  11. Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards.
    Martin RM, Fowler JL, Cromer MK, Lesch BJ, Ponce E, Uchida N, Nishimura T, Porteus MH, Loh KM| | PubMed
  12. Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination.
    Martin RM, Ikeda K, Cromer MK, Uchida N, Nishimura T, Romano R, Tong AJ, Lemgart VT, Camarena J, Pavel-Dinu M, Sindhu C, Wiebking V, Vaidyanathan S, Dever DP, Bak RO, Laustsen A, Lesch BJ, Jakobsen MR, Sebastiano V, Nakauchi H, Porteus MH| | PubMed
  13. Identification of preexisting adaptive immunity to Cas9 proteins in humans.
    Charlesworth CT, Deshpande PS, Dever DP, Camarena J, Lemgart VT, Cromer MK, Vakulskas CA, Collingwood MA, Zhang L, Bode NM, Behlke MA, Dejene B, Cieniewicz B, Romano R, Lesch BJ, Gomez-Ospina N, Mantri S, Pavel-Dinu M, Weinberg KI, Porteus MH| | PubMed
  14. Global Transcriptional Response to CRISPR/Cas9-AAV6-Based Genome Editing in CD34+ Hematopoietic Stem and Progenitor Cells.
    Cromer MK, Vaidyanathan S, Ryan DE, Curry B, Lucas AB, Camarena J, Kaushik M, Hay SR, Martin RM, Steinfeld I, Bak RO, Dever DP, Hendel A, Bruhn L, Porteus MH| | PubMed
  15. Priming Human Repopulating Hematopoietic Stem and Progenitor Cells for Cas9/sgRNA Gene Targeting.
    Charlesworth CT, Camarena J, Cromer MK, Vaidyanathan S, Bak RO, Carte JM, Potter J, Dever DP, Porteus MH| | PubMed
  16. Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.
    Cromer MK, Choi M, Nelson-Williams C, Fonseca AL, Kunstman JW, Korah RM, Overton JD, Mane S, Kenney B, Malchoff CD, Stalberg P, Akerström G, Westin G, Hellman P, Carling T, Björklund P, Lifton RP| | PubMed
  17. Identification of somatic mutations in parathyroid tumors using whole-exome sequencing.
    Cromer MK, Starker LF, Choi M, Udelsman R, Nelson-Williams C, Lifton RP, Carling T| | PubMed